Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men
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چکیده
منابع مشابه
Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men.
Narcolepsy is a sleep disorder caused by disruption of hypocretin (orexin) neurotransmission. Injection of hypocretin-1 acutely suppresses TRH and TSH release in rats. In contrast, subchronic administration does not appear to affect the hypothalamo-pituitary-thyroid ensemble in animals. We explored (in 7 patients and 7 controls) whether hypocretin deficiency impacts circulating TSH levels and c...
متن کاملThe somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH secretory events
Narcolepsy is a sleep disorder caused by impaired hypocretin (orexin) neurotransmission. Growth hormone (GH) secretion may be altered in narcolepsy for various reasons. Slow wave sleep episodes, which are closely associated with GH secretory events, are more randomly dispersed over 24 hours in narcoleptics. Furthermore, hypocretins may inhibit pituitary GH release. We assessed the function of t...
متن کاملSomatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events.
Narcolepsy is a sleep disorder caused by impaired hypocretin (orexin) neurotransmission. Growth hormone (GH) secretion may be altered in narcolepsy for various reasons. Slow-wave sleep episodes, which are closely associated with GH-secretory events, are more randomly dispersed over 24 h in narcoleptics. Furthermore, hypocretins may inhibit pituitary GH release. We assessed the function of the s...
متن کاملPulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men.
Hypocretin (orexin) peptides are involved in the regulation of energy balance and pituitary hormone release. Narcolepsy is a sleep disorder characterized by disruption of hypocretin neurotransmission. Pituitary LH secretion is diminished in hypocretin-deficient animal models, and intracerebroventricular administration of hypocretin-1 activates the hypothalamo-pituitary-gonadal axis in rats. We ...
متن کاملThe Pituitary-Thyroid Axis in Acromegaly
The pituitary-Thyroid axis of 12 Acromegalic patients was evaluated by measurement of the concentration (Total and free of thyroxine T4, T3 and revers T3 (rT3) and TSH, GH and prolactin before and after in stimulation with TRH. Using an ultrasensitive method of TSH measurement (IRMA) basal serum TSH levels of patients (0.76, 0.07-l.90mlU/L) were found slightly but significantly (P < 0.01), low...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2005
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00327.2004